The St. Dominic Center and St. Dominic Village is just east of the Texas Medical Center at the corner of Holcombe Blvd. and Almeda Rd. The gated entrance faces Holcombe Blvd. (no access from Almeda). There is a Holcombe exit on Highway 288 from either direction.

FROM DOWNTOWN using Fannin, you may turn left on ALABAMA or WHEELER, then (after several blocks) right on Almeda, to avoid the Holcombe Blvd. overpass and the Medical Center traffic. No left turns are allowed from Main Street until you are near the Medical Center.